11 articles - From Friday Dec 30 2022 to Friday Jan 06 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Am J Kidney Dis |
Associations of Iron Sucrose and Intradialytic Blood Pressure. We observed an independent association of intravenous IS administration during HD with a lower risk of intradialytic hypotension and higher risk of intradialytic hypertension. Future studies to better understand the mechanisms underlying these associations are warranted. |
Early Postoperative Acetaminophen Administration and Severe Acute Kidney Injury After Cardiac Surgery. Early postoperative acetaminophen administration was independently associated with a lower risk of severe AKI in adults recovering from cardiac surgery. Prospective trials are warranted to assess the extent to which the observed association is causal and estimate the extent to which acetaminophen administration might prevent or reduce the severity of AKI. |
Subcutaneous C.E.R.A. for the Maintenance Treatment of Anemia in Pediatric Patients With CKD: A Phase 2, Open-Label, Single-Arm, Multicenter Study. Pediatric patients with anemia secondary to CKD who were on, or not on, dialysis could be safely and effectively switched from maintenance ESAs to C.E.R.A. SC every 4 weeks, using defined dose-conversion factors to determine the optimum starting dose. |
| Kidney Int |
Pathological characteristics of light chain crystalline podocytopathy. In sum, LCCP is rare, mostly associates with IgG |
The transcription factor ATF4 mediates endoplasmic reticulum stress related podocyte injury and slit diaphragm defects. These findings are conserved in human podocytes where ATF4 inhibition improved the viability of podocytes with OSGEP knockdown, with chemically-induced ER stress, and where ATF4 target genes and pro-apoptotic gene clusters are upregulated upon OSGEP knockdown. Thus, our data identify ATF4 mediated signaling as a molecular link between ER stress, slit diaphragm defects, podocyte injury, and suggest that modulation of ATF4 signaling may be a potential therapeutic target for certain podocyte diseases. |
Ubiquitin-specific protease 11 promotes partial epithelial-to-mesenchymal transition by deubiquitinating the epidermal growth factor receptor during kidney fibrosis. Moreover, USP11 deletion had anti-fibrotic and anti-inflammatory kidney effects in the murine HN and FA models. Thus, our study provides evidence supporting USP11 as a promising target for minimizing kidney fibrosis and that inhibition of USP11 has potential to be an effective strategy for patients with chronic kidney disease. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Nat Rev Nephrol |
Gasdermins and pyroptosis in the kidney. The well-documented roles of inflammasome activity and apoptosis pathways in kidney diseases suggests that gasdermins and pyroptosis may also be involved to some extent. However, despite some evidence for involvement of pyroptosis in the context of acute kidney injury and chronic kidney disease, our understanding of gasdermin biology and pyroptosis in the kidney remains limited. |
Role of necroptosis in kidney health and disease. Despite evidence of a link between necroptosis and various kidney diseases, there are no available therapeutic options to target this process. Greater understanding of the molecular mechanisms, triggers and regulators of necroptosis in acute and chronic kidney diseases may identify shortcomings in current approaches to therapeutically target necroptosis regulators and lead to the development of innovative therapeutic approaches. |
| Semin Nephrol |
Ethics and Theoretical Issues in Kidney Xenotransplantation. Ultimately, the benefits are to those patients suffering from the many and various diseases that drive the need for xenotransplantation. The hope is that it will be implemented as soon as possible to help the many millions of patients who can truly benefit. |
misc publications eg case reports, tools of the trade, images of the month, etc…
Letters to the editors and authors’ replies
| Am J Kidney Dis |